Article

Human T cells employ conserved AU-rich elements to fine-tune IFN-γ production

2019-11-04

Abstract excerpt

<h4>ABSTRACT</h4> Long-lasting CD8 + T cell responses are critical in combatting infections and tumors. The pro-inflammatory cytokine IFN-γ is a key effector molecule herein. We recently showed that in murine T cells, the production of IFN-γ is tightly regulated through AU-rich elements (AREs) that are located in the 3’ Untranslated Region (UTR). Loss of AREs resulted in prolonged cytokine production in activate...

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Literature Corpus work: 41ff728b-de4c-57a2-b610-294ff2b99259
DOI: 10.1101/830042

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