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Single-cell CRISPR screening characterizes transcriptional deregulation in T-cell acute lymphoblastic leukemia

2023-12-21

Abstract excerpt

<title>Abstract</title> <p> T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of leukemia caused by accumulation of multiple genetic alterations in T-cell progenitors. However, for many genes it remains unknown how their mutation contributes to disease development. Therefore, we performed two single-cell CRISPR screens in primary pro-T cells <italic>ex vivo</italic> to study the transcriptional...

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Literature Corpus work
475ac00e-5f41-5fe0-b550-7d2f2cc20dc8
DOI
10.21203/rs.3.rs-2615765/v2
Open publication

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Single-cell CRISPR screening characterizes transcriptional deregulation in T-cell acute lymphoblastic leukemiaDOI 10.21203/rs.3.rs-2615765/v2
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