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The Circadian Clock Gates the Intestinal Stem Cell Regenerative State

1 Apr 2013

Abstract excerpt

The intestine has evolved under constant environmental stresses, because an animal may ingest harmful pathogens or chemicals at any time during its lifespan. Following damage, intestinal stem cells (ISCs) regenerate the intestine by proliferating to replace dying cells. ISCs from diverse animals are remarkably similar, and the Wnt, Notch, and Hippo signaling pathways, important regulators of mammalian ISCs, are...

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PMID: 23583176
DOI: 10.1016/j.celrep.2013.03.016

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