Article
Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms.
Nature communications - 6 Apr 2024
Zhang Peiwen, You Na, Ding Yiyi, Zhu Wenqi, Wang Nan, Xie Yueqiao, Huang Wanling, Ren Qian, Qin Tiejun, Fu Rongfeng, Zhang Lei, Xiao Zhijian, Cheng Tao, Ma Xiaotong
Abstract excerpt
Despite the identification of driver mutations leading to the initiation of myeloproliferative neoplasms (MPNs), the molecular pathogenesis of MPNs remains incompletely understood. Here, we demonstrate that growth arrest and DNA damage inducible gamma (GADD45g) is expressed at significantly lower levels in patients with MPNs, and JAK2V617F mutation and histone deacetylation contribute to its reduced expression....
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