Article
Altered erythropoiesis via JAK2 and ASXL1 mutations in myeloproliferative neoplasms.
Experimental hematology - 1 Apr 2024
Collins Taylor B, Laranjeira Angelo B A, Kong Tim, Fulbright Mary C, Fisher Daniel A C, Sturgeon Christopher M, Batista Luis F Z, Oh Stephen T
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are driven by hyperactivation of JAK-STAT signaling but can demonstrate skewed hematopoiesis upon acquisition of additional somatic mutations. Here, using primary MPN samples and engineered embryonic stem cells, we demonstrate that mutations in JAK2 induced a significant increase in erythroid colony formation, whereas mutations in additional sex combs-like 1 (ASXL1) led to an...
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