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Article

Discovering novel driver mutations from pan-cancer analysis of mutational and gene expression profiles.

PloS one - 1 Jan 2020

Tegally Houriiyah, Kensler Kevin H, Mungloo-Dilmohamud Zahra, Ghoorah Anisah W, Rebbeck Timothy R, Baichoo Shakuntala

Abstract excerpt

As the genomic profile across cancers varies from person to person, patient prognosis and treatment may differ based on the mutational signature of each tumour. Thus, it is critical to understand genomic drivers of cancer and identify potential mutational commonalities across tumors originating at diverse anatomical sites. Large-scale cancer genomics initiatives, such as TCGA, ICGC and GENIE have enabled the...

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Share to Databases, Nucleic Acid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33232371
DOI: 10.1371/journal.pone.0242780
PMCID: PMC7685479

Genes

MXRA5
OBSCN
RYR1
TG

Provenance

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