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Article

The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization.

The Journal of biological chemistry - 12 Sept 2014

Chen Xiaoyong, Wilson James B, McChesney Patricia, Williams Stacy A, Kwon Youngho, Longerich Simonne, Marriott Andrew S, Sung Patrick, Jones Nigel J, Kupfer Gary M

Abstract excerpt

Fanconi anemia is a genetic disease resulting in bone marrow failure, birth defects, and cancer that is thought to encompass a defect in maintenance of genomic stability. Mutations in 16 genes (FANCA, B, C, D1, D2, E, F, G, I, J, L, M, N, O, P, and Q) have been identified in patients, with the Fanconi anemia subtype J (FA-J) resulting from homozygous mutations in the FANCJ gene. Here, we describe the direct...

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Share to Basic-Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25070891
DOI: 10.1074/jbc.M114.552570
PMCID: PMC4162179

Genes

FANCD2
FANCA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization.PMID 25070891Read ↗

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