Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Insights into Fanconi Anaemia from the structure of human FANCE.

Nucleic acids research - 1 Jan 2007

Nookala Ravi K, Hussain Shobbir, Pellegrini Luca

Abstract excerpt

Fanconi Anaemia (FA) is a cancer predisposition disorder characterized by spontaneous chromosome breakage and high cellular sensitivity to genotoxic agents. In response to DNA damage, a multi-subunit assembly of FA proteins, the FA core complex, monoubiquitinates the downstream FANCD2 protein. The FANCE protein plays an essential role in the FA process of DNA repair as the FANCD2-binding component of the FA core...

Topics

Join the communities discussing this publication.

Crystallography, X-Ray
Fanconi Anemia
Fanconi Anemia Complementation Group D2 Protein
Models, Molecular
Protein Structure, Tertiary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Amino Acid

Sequence Alignment

Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 17308347
DOI: 10.1093/nar/gkm033
PMCID: PMC1865054

Genes

FANCD2
FANCE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights into Fanconi Anaemia from the structure of human FANCE.PMID 17308347Read ↗

Structural insight into FANCI-FANCD2 monoubiquitination.Semantic proximity Read ↗

Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.Semantic proximity Read ↗

Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex.Semantic proximity Read ↗

FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway.Semantic proximity Read ↗

The Carboxyl Terminus of FANCE Recruits FANCD2 to the Fanconi Anemia (FA) E3 Ligase Complex to Promote the FA DNA Repair PathwaySemantic proximity Read ↗

Fanconi anaemia and cancer: an intricate relationship.Semantic proximity Read ↗

Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia.Semantic proximity Read ↗

Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair PathwaySemantic proximity Read ↗

Exome sequencing reveals a novel Fanconi group defined by XRCC2 mutation: Figure 1Semantic proximity Read ↗

Expanded roles of the Fanconi anemia pathway in preserving genomic stability.Semantic proximity Read ↗

Characterization of FANCL variants observed in patient cancer cells.Semantic proximity Read ↗

Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.