Article

Effects of overexpressing wild-type and variant Rad52 on homologous recombination in human cells

2012-01-01

Abstract excerpt

Mitotic homologous recombination (HR) stabilises the genome by repairing harmful double stranded DNA (dsDNA) breaks. Rad52 promotes the annealing of complementary DNA strands and binds to Rad51 suggesting that Rad52 acts in both strand invasion (SI) and single strand annealing (SSA) HR pathways. Overexpression of Rad52 in mammalian cells can greatly stimulate HR, but the degree of stimulation varies widely between...

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Literature Corpus work: 71b1f004-0ec6-51d1-b319-53febf1eb3d3
DOI: 10.25560/9200

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