Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations altering the DNA binding domains of the human RAD52 protein exert distinct effects on homologous recombination repair in Saccharomyces cerevisiae.

G3 (Bethesda, Md.) - 4 Feb 2026

Manthey Glenn M, Wolf Elise W, Xu Jason, Negritto M Cristina, Bouley Renee A, Petreaca Ruben C, Bailis Adam M

Abstract excerpt

RAD52 is a conserved member of the homologous recombination repair (HRR) apparatus from yeast to humans. Mutating conserved amino acids in the internal and external DNA binding domains of the human RAD52 protein (HsRAD52) has discrete effects in vitro. Previous studies have shown that HsRAD52 supports multiple mechanisms of HRR in budding yeast, suggesting the utility of this model system for exploring the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Breaks, Double-Stranded
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Binding

Share to Protein Domains

Share to Rad52 DNA Repair and Recombination Protein

Share to Recombinational DNA Repair

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 41275418
DOI: 10.1093/g3journal/jkaf282
PMCID: PMC12869081

Genes

RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations altering the DNA binding domains of the human RAD52 protein exert distinct effects on homologous recombination repair in Saccharomyces cerevisiae.PMID 41275418Read ↗

Homologous recombination in budding yeast expressing the human RAD52 gene reveals a Rad51-independent mechanism of conservative double-strand break repair.Semantic proximity Read ↗

Reappearance from Obscurity: Mammalian Rad52 in Homologous RecombinationSemantic proximity Read ↗

Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic AdvancementSemantic proximity Read ↗

Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break RepairSemantic proximity Read ↗

Identification of residues important for DNA binding in the full-length human Rad52 protein.Semantic proximity Read ↗

Effects of overexpressing wild-type and variant Rad52 on homologous recombination in human cellsSemantic proximity Read ↗

Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.Semantic proximity Read ↗

Functional Validation of Rare Human Genetic Variants Involved in Homologous Recombination Using Saccharomyces cerevisiae.Semantic proximity Read ↗

Emerging Roles of RAD52 in Genome MaintenanceSemantic proximity Read ↗

Pan-cancer analysis of co-occurring mutations in RAD52 and the BRCA1-BRCA2-PALB2 axis in human cancers.Semantic proximity Read ↗

The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiae.Semantic proximity Read ↗

Novel structural insights on full-length human RAD52: Cryo-EM and beyondSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.