Article

Design of time-delayed safety switches for CRISPR gene therapy

2021-04-18

Abstract excerpt

CRISPR system is a powerful gene editing tool which has already been reported to address a variety of gene relevant diseases in different cell lines. However, off-target effect and immune response caused by Cas9 remain two fundamental problems. Inspired by previously reported Cas9 self-elimination systems, time-delayed safety switches are designed in this work. Firstly, ultrasensitive relationship is constructed b...

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Identifiers and source

Literature Corpus work: 7197cdce-25f6-56d7-a04b-10546a47fffb
DOI: 10.1101/2021.04.17.440285

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