Article

A molecular glue approach to control the half-life of CRISPR-based technologies

2023-03-12

Abstract excerpt

Cas9 is a programmable nuclease that has furnished transformative technologies, including base editors and transcription modulators (e.g., CRISPRi/a), but several applications of these technologies, including therapeutics, mandatorily require precision control of their half-life. For example, such control can help avert any potential immunological and adverse events in clinical trials. Current genome editing techn...

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Literature Corpus work: 22311d99-c270-550a-bbed-66295458576d
DOI: 10.1101/2023.03.12.531757

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