Article

Restriction of SARS-CoV-2 Replication by Targeting Programmed −1 Ribosomal Frameshifting In Vitro

2020-10-21

Abstract excerpt

<h4>SUMMARY</h4> Translation of open reading frame 1b (ORF1b) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires programmed −1 ribosomal frameshifting (−1 PRF) promoted by an RNA pseudoknot. The extent to which SARS-CoV-2 replication may be sensitive to changes in −1 PRF efficiency is currently unknown. Through an unbiased, reporter-based high-throughput compound screen, we identified merafl...

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Literature Corpus work: 71759c07-e2eb-55a0-bf1a-4db4b4e7e3ff
DOI: 10.1101/2020.10.21.349225

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