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Article

Anti-Frameshifting Ligand Active against SARS Coronavirus-2 Is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot.

Journal of molecular biology - 2 Oct 2020

Neupane Krishna, Munshi Sneha, Zhao Meng, Ritchie Dustin B, Ileperuma Sandaru M, Woodside Michael T

Abstract excerpt

SARS-CoV-2 uses -1 programmed ribosomal frameshifting (-1 PRF) to control expression of key viral proteins. Because modulating -1 PRF can attenuate the virus, ligands binding to the RNA pseudoknot that stimulates -1 PRF may have therapeutic potential. Mutations in the pseudoknot have occurred during the pandemic, but how they affect -1 PRF efficiency and ligand activity is unknown. Studying a panel of six...

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Identifiers

PMID: 32920049
DOI: 10.1016/j.jmb.2020.09.006
PMCID: PMC7483078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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