Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses

18 Jan 2022

Abstract excerpt

Recurrent outbreaks of novel zoonotic coronavirus (CoV) diseases in recent years have highlighted the importance of developing therapeutics with broad-spectrum activity against CoVs. Because all CoVs use -1 programmed ribosomal frameshifting (-1 PRF) to control expression of key viral proteins, the frameshift signal in viral mRNA that stimulates -1 PRF provides a promising potential target for such therapeutics....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Peptides and Activities
Share to Influenza Virus Research Studies
Share to RNA and protein synthesis mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35215770
DOI: 10.3390/v14020177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of CoronavirusesPMID 35215770Read ↗

Programmed -1 Ribosomal Frameshifting in coronaviruses: A therapeutic target.Semantic proximity Read ↗

Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)Semantic proximity Read ↗

Anti-Frameshifting Ligand Active against SARS Coronavirus-2 Is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot.Semantic proximity Read ↗

Targeting Ribosomal Frameshifting as an Antiviral Strategy: From HIV-1 to SARS-CoV-2Semantic proximity Read ↗

Biological Significance and Therapeutic Promise of Programmed Ribosomal FrameshiftingSemantic proximity Read ↗

Programmed −1 ribosomal frameshifting in the SARS coronavirusSemantic proximity Read ↗

Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshiftingSemantic proximity Read ↗

Restriction of SARS-CoV-2 replication by targeting programmed -1 ribosomal frameshifting.Semantic proximity Read ↗

Restriction of SARS-CoV-2 Replication by Targeting Programmed −1 Ribosomal Frameshifting In VitroSemantic proximity Read ↗

Peptidyl-transferase inhibitors have antiviral properties by altering programmed −1 ribosomal frameshifting efficiencies: Development of model systemsSemantic proximity Read ↗

Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Among cis-Acting RNA ElementsSemantic proximity Read ↗

High-throughput interrogation of programmed ribosomal frameshifting in human cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.