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Article

Restriction of SARS-CoV-2 replication by targeting programmed -1 ribosomal frameshifting.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2021

Sun Yu, Abriola Laura, Niederer Rachel O, Pedersen Savannah F, Alfajaro Mia M, Silva Monteiro Valter, Wilen Craig B, Ho Ya-Chi, Gilbert Wendy V, Surovtseva Yulia V, Lindenbach Brett D, Guo Junjie U

Abstract excerpt

Translation of open reading frame 1b (ORF1b) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires a programmed -1 ribosomal frameshift (-1 PRF) promoted by an RNA pseudoknot. The extent to which SARS-CoV-2 replication may be sensitive to changes in -1 PRF efficiency is currently unknown. Through an unbiased, reporter-based high-throughput compound screen, we identified merafloxacin, a...

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Identifiers

PMID: 34185680
DOI: 10.1073/pnas.2023051118
PMCID: PMC8256030

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