Article

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1

2021-12-13

Abstract excerpt

A significant proportion of infant B-cell acute lymphoblastic leukemia (B-ALL) patients remains with a dismal prognosis due to yet undetermined mechanisms. We performed a comprehensive multicohort analysis of gene expression, gene fusions, and RNA splicing alterations to uncover molecular signatures potentially linked to the observed poor outcome. We identified 87 fusions with significant allele frequency across p...

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Literature Corpus work: 716a6785-2b86-5966-b2e7-34ea245b1484
DOI: 10.1101/2021.12.13.472370

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