Article

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1

2022-01-12

Abstract excerpt

<title>Abstract</title> <p>A significant proportion of B-cell acute lymphoblastic leukemia (B-ALL) patients remains with a dismal prognosis due to yet undetermined mechanisms. We performed a comprehensive multicohort analysis of gene fusions, gene expression, and RNA splicing alterations to uncover molecular signatures potentially linked to the observed poor outcome. We identified 84 fusions with significant alle...

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Literature Corpus work: 1102124b-3264-59e0-82dc-f2ac1dfdfa5d
DOI: 10.21203/rs.3.rs-1168367/v1

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