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Article

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1

28 Sept 2022

Abstract excerpt

Abstract A significant proportion of infant B-cell acute lymphoblastic leukemia (B-ALL) patients remains with a dismal prognosis due to yet undetermined mechanisms. We performed a comprehensive multicohort analysis of gene expression, gene fusions, and RNA splicing alterations to uncover molecular signatures potentially linked to the observed poor outcome. We identified 87 fusions with significant allele...

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PMID: 36518527
DOI: 10.1093/narcan/zcac041

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