Article
Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia.
Blood advances - 22 Oct 2019
Shiba Norio, Yoshida Kenichi, Hara Yusuke, Yamato Genki, Shiraishi Yuichi, Matsuo Hidemasa, Okuno Yusuke, Chiba Kenichi, Tanaka Hiroko, Kaburagi Taeko, Takeuchi Masanobu, Ohki Kentaro, Sanada Masashi, Okubo Jun, Tomizawa Daisuke, Taki Tomohiko, Shimada Akira, Sotomatsu Manabu, Horibe Keizo, Taga Takashi, Adachi Souichi, Tawa Akio, Miyano Satoru, Ogawa Seishi, Hayashi Yasuhide
Abstract excerpt
Recent advances in the genetic understanding of acute myeloid leukemia (AML) have improved clinical outcomes in pediatric patients. However, ∼40% of patients with pediatric AML relapse, resulting in a relatively low overall survival rate of ∼70%. The objective of this study was to reveal the comprehensive genetic background of pediatric AML. We performed transcriptome analysis (RNA sequencing [RNA-seq]) in 139 of...
Topics
Join the communities discussing this publication.