Article
Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 2018
Chen Bing, Jiang Lu, Zhong Meng-Ling, Li Jian-Feng, Li Ben-Shang, Peng Li-Jun, Dai Yu-Ting, Cui Bo-Wen, Yan Tian-Qi, Zhang Wei-Na, Weng Xiang-Qin, Xie Yin-Yin, Lu Jing, Ren Rui-Bao, Chen Su-Ning, Hu Jian-Da, Wu De-Pei, Chen Zhu, Tang Jing-Yan, Huang Jin-Yan, Mi Jian-Qing, Chen Sai-Juan
Abstract excerpt
T-cell acute lymphoblastic leukemia (T-ALL) is a clonal malignancy of immature T cells. Recently, the next-generation sequencing approach has allowed systematic identification of molecular features in pediatric T-ALL. Here, by performing RNA-sequencing and other genomewide analysis, we investigated the genomic landscape in 61 adult and 69 pediatric T-ALL cases. Thirty-six distinct gene fusion transcripts were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.