NUTM1 is a recurrent fusion gene partner in B-cell precursor acute lymphoblastic leukemia associated with increased expression of genes on chromosome band 10p12.31-12.2

Abstract excerpt

For 20-25% of patients with pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), the driving cytogenetic aberration is unknown. Identification of the primary lesion could provide better risk stratification and even identify possible treatment options. We therefore aimed to find novel recurrent genetic aberrations in BCP-ALL cases. We identified an in-frame SLC12A6-NUTM1 fusion, resulting in...

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