Article

CD73 maintains hepatocyte metabolic integrity and mouse liver homeostasis in a sex-dependent manner

2020-10-08

Abstract excerpt

<h4>Background & Aims</h4> Metabolic imbalance and inflammation are common features of chronic liver diseases. Molecular factors controlling these mechanisms represent potential therapeutic targets. One promising target is CD73, the major enzyme that dephosphorylates extracellular adenosine monophosphate (AMP) to form the anti-inflammatory adenosine. In normal liver, CD73 is expressed on pericentral hepatocytes,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3bf5b2f4-b8c9-5b47-b894-0a1e73dcb454
DOI: 10.1101/2020.10.08.328930

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CD73 maintains hepatocyte metabolic integrity and mouse liver homeostasis in a sex-dependent mannerDOI 10.1101/2020.10.08.328930Read

CD73 generated extracellular adenosine promotes resolution of neutrophil-mediated tissue injury and restrains metaplasia in pancreatitisSemantic proximity Read

Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH)Semantic proximity Read

Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in MiceSemantic proximity Read

Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Injury in a Mouse Model of Metabolic Dysfunction-associated Steatotic Liver DiseaseSemantic proximity Read

Single‐cell transcriptome analysis of aging mouse liverSemantic proximity Read

CXCR3+ LEF1low NK cells cause immunopathological hepatic damage in MASHSemantic proximity Read

Human-Mouse Convergence in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mouse Model Selection and Non-Invasive Diagnostic StrategiesSemantic proximity Read

Circadian Clock and Liver CancerSemantic proximity Read

The Lipid Hydrolase ABHD6 is a Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Hepatocellular CarcinomaSemantic proximity Read

Circadian Regulation of Gene Expression and Metabolism in the LiverSemantic proximity Read

Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling moduleSemantic proximity Read

Autoimmunity in CD73/Ecto-5'-nucleotidase deficient mice induces renal injury.Semantic proximity Read