Article

Co-targeting menin and LSD1 dismantles oncogenic programs and restores differentiation in MLL-rearranged AML

2025-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Acute myeloid leukemia (AML) harboring MLL ( MLL1, KMT2A ) rearrangement ( MLL-r ) remains a lethal subtype with limited durable responses to single-agent menin inhibition. To define rational combination strategies, we performed a high-throughput screen of >900 epigenetic modulators in combination with menin inhibition in MLL-r AML models. This uncovered consistent synergy between menin and...

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Literature Corpus work: 1be48c91-4f89-5201-9503-250e3d78f297
DOI: 10.1101/2025.10.13.681683

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