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Article

Expression quantitative trait loci (eQTL): from population genetics to precision medicine.

Journal of genetics and genomics = Yi chuan xue bao - 1 Apr 2025

Wong Zhi Qi, Deng Lian, Cengnata Alvin, Abdul Rahman Thuhairah, Mohd Ismail Aletza, Hong Lim Renee Lay, Xu Shuhua, Hoh Boon-Peng

Abstract excerpt

Evidence has shown that differential transcriptomic profiles among human populations from diverse ancestries, supporting the role of genetic architecture in regulating gene expression alongside environmental stimuli. Genetic variants that regulate gene expression, known as expression quantitative trait loci (eQTL), are primarily shaped by human migration history and evolutionary forces, likewise, regulation of...

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PMID: 39986349
DOI: 10.1016/j.jgg.2025.02.003

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