Genes with differential expression across ancestries are enriched in ancestry-specific disease effects likely due to gene-by-environment interactions.

Abstract excerpt

Multi-ancestry genome-wide association studies (GWASs) have highlighted the existence of variants with ancestry-specific effect sizes. Understanding where and why these ancestry-specific effects occur is fundamental to understanding the genetic basis of human diseases and complex traits. Here, we characterized genes differentially expressed across ancestries (ancDE genes) at the cell-type level by leveraging...

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