Article

Ancestry-specific regulatory and disease architectures are likely due to cell-type-specific gene-by-environment interactions

2023-10-21

Abstract excerpt

Multi-ancestry genome-wide association studies (GWAS) have highlighted the existence of variants with ancestry-specific effect sizes. Understanding where and why these ancestry-specific effects occur is fundamental to understanding the genetic basis of human diseases and complex traits. Here, we characterized genes differentially expressed across ancestries (ancDE genes) at the cell-type level by leveraging single...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 644cb427-8423-5792-961f-df9b0e301311
DOI: 10.1101/2023.10.20.23297214

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ancestry-specific regulatory and disease architectures are likely due to cell-type-specific gene-by-environment interactionsDOI 10.1101/2023.10.20.23297214Read

Genes with differential expression across ancestries are enriched in ancestry-specific disease effects likely due to gene-by-environment interactions.Semantic proximity Read

Local ancestry modulates gene expression: shifting our understanding of genetic regulation and disease association within and across populationsSemantic proximity Read

Population-specific causal disease effect sizes in functionally important regions impacted by selectionSemantic proximity Read

On Using Local Ancestry to Characterize the Genetic Architecture of Human Phenotypes: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations as a ModelSemantic proximity Read

traceCB: Trans-ancestry cell-type-specific eQTLs mapping by integrating scRNA-seq and bulk dataSemantic proximity Read

Genetic and environmental contributions to ancestry differences in gene expression in the human brainSemantic proximity Read

Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies.Semantic proximity Read

Genetic and environmental contributions to ancestry differences in gene expression in the human brainSemantic proximity Read

MATS: a novel multi-ancestry transcriptome-wide association study to account for heterogeneity in the effects of cis-regulated gene expression on complex traits.Semantic proximity Read

Multi-ancestry gene-trait connection landscape using electronic health record (EHR) linked biobank dataSemantic proximity Read

Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studiesSemantic proximity Read

Population-specific causal disease effect sizes in functionally important regions impacted by selection.Semantic proximity Read