Article

Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier

2023-01-13

Abstract excerpt

The blood-brain barrier (BBB) presents a major challenge to delivering large molecules to study and treat the central nervous system (CNS). This is due in part to the scarcity of effective targets for BBB crossing, the identification of which is the crucial first step of drug development. Here, we leveraged a panel of adeno-associated viruses (AAVs) previously identified through directed evolution for improved BBB...

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Literature Corpus work: 70f6fbb1-4e87-5377-8b9c-727ef7c5e076
DOI: 10.1101/2023.01.12.523632

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