Article

Highly conserved brain vascular receptor ALPL mediates transport of engineered viral vectors across the blood-brain barrier

2024-03-14

Abstract excerpt

Delivery of systemically administered therapeutics to the central nervous system (CNS) is restricted by the blood-brain barrier (BBB). Bioengineered Adeno-Associated Virus (AAV) capsids have been shown to penetrate the BBB with great efficacy in mouse and non-human primate models, but their translational potential is often limited by species selectivity and undefined mechanisms of action. Here, we apply our RNA-gu...

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Literature Corpus work: c3a22446-5b89-5408-af5e-9d67d6761a73
DOI: 10.1101/2024.03.12.584703

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