Article

VCAP-102 Achieves Exceptional BBB Penetration in Marmosets After Ten Years of AAV Capsid Evaluation

2025-12-09

Abstract excerpt

Efficient passage of adenoassociated virus (AAV) vectors across the blood–brain barrier (BBB) is essential for achieving broad central nervous system transduction following systemic delivery. Since PHP.B was reported in 2016 to exhibit high BBB permeability in C57BL/6J mice, many BBB-penetrant capsids have been developed, yet their performance often varies substantially across species. From 2016 to 2025, we produc...

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Literature Corpus work: b406f7bc-13e5-56f5-8c4f-585f8a3fbf09
DOI: 10.64898/2025.12.06.692617

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