Article

Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids

2019-02-01

Abstract excerpt

The engineered AAV-PHP.B family of adeno-associated virus efficiently delivers genes throughout the mouse central nervous system. To guide their application across disease models, and to inspire the development of translational gene therapy vectors useful for targeting neurological diseases in humans, we sought to elucidate the host factors responsible for the CNS tropism of AAV-PHP.B vectors. Leveraging CNS tropi...

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Literature Corpus work: e92e27c2-8e91-5b7c-be80-5ce2705dcd4f
DOI: 10.1101/538421

Open publication

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