Article
Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids.
PloS one - 1 Jan 2019
Huang Qin, Chan Ken Y, Tobey Isabelle G, Chan Yujia Alina, Poterba Tim, Boutros Christine L, Balazs Alejandro B, Daneman Richard, Bloom Jonathan M, Seed Cotton, Deverman Benjamin E
Abstract excerpt
The engineered AAV-PHP.B family of adeno-associated virus efficiently delivers genes throughout the mouse central nervous system. To guide their application across disease models, and to inspire the development of translational gene therapy vectors for targeting neurological diseases in humans, we sought to elucidate the host factors responsible for the CNS tropism of the AAV-PHP.B vectors. Leveraging CNS tropism...
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