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Article

CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection

17 Oct 2023

Abstract excerpt

Unlike most RNA and DNA viruses that broadly stimulate mRNA decay and interfere with host gene expression, human cytomegalovirus (HCMV) extensively remodels the host translatome without producing an mRNA decay enzyme. By performing a targeted loss-of-function screen in primary human fibroblasts, we here identify the host CCR4-NOT deadenylase complex members CNOT1 and CNOT3 as unexpected pro-viral host factors...

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PMID: 37846490
DOI: 10.15252/embr.202256327

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