DDX3 depletion represses translation of mRNAs with complex 5′ UTRs

Abstract excerpt

DDX3 is an RNA chaperone of the DEAD-box family that regulates translation. Ded1, the yeast ortholog of DDX3, is a global regulator of translation, whereas DDX3 is thought to preferentially affect a subset of mRNAs. However, the set of mRNAs that are regulated by DDX3 are unknown, along with the relationship between DDX3 binding and activity. Here, we use ribosome profiling, RNA-seq, and PAR-CLIP to define the set...

Topics

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• 5' Untranslated Regions
• DEAD-box RNA Helicases
• HEK293 Cells
• Mutation
• Protein Biosynthesis
• RNA, Messenger
• RNA, Ribosomal
• RNA, Small Interfering

Identifiers and source

Literature Corpus work

40cc5d92-ee2f-5d20-bcdc-ced8a6a5f5c7

DOI

10.1101/589218