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Article

Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis

15 Mar 2024

Abstract excerpt

Protein synthesis is frequently deregulated during tumorigenesis. However, the precise contexts of selective translational control and the regulators of such mechanisms in cancer is poorly understood. Here, we uncovered CNOT3, a subunit of the CCR4-NOT complex, as an essential modulator of translation in myeloid leukemia. Elevated CNOT3 expression correlates with unfavorable outcomes in patients with acute...

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PMID: 38491013
DOI: 10.1038/s41467-024-46665-2

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