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Article

DDX3 depletion represses translation of mRNAs with complex 5' UTRs.

Nucleic acids research - 21 May 2021

Calviello Lorenzo, Venkataramanan Srivats, Rogowski Karol J, Wyler Emanuel, Wilkins Kevin, Tejura Malvika, Thai Bao, Krol Jacek, Filipowicz Witold, Landthaler Markus, Floor Stephen N

Abstract excerpt

DDX3 is an RNA chaperone of the DEAD-box family that regulates translation. Ded1, the yeast ortholog of DDX3, is a global regulator of translation, whereas DDX3 is thought to preferentially affect a subset of mRNAs. However, the set of mRNAs that are regulated by DDX3 are unknown, along with the relationship between DDX3 binding and activity. Here, we use ribosome profiling, RNA-seq, and PAR-CLIP to define the...

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Share to 5' Untranslated Regions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33905506
DOI: 10.1093/nar/gkab287
PMCID: PMC8136831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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