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Article

The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control.

PloS one - 1 Jan 2014

Halter David, Collart Martine A, Panasenko Olesya O

Abstract excerpt

Eukaryotic cells control their proteome by regulating protein production and protein clearance. Protein production is determined to a large extent by mRNA levels, whereas protein degradation depends mostly upon the proteasome. Dysfunction of the proteasome leads to the accumulation of non-functional proteins that can aggregate, be toxic for the cell, and, in extreme cases, lead to cell death. mRNA levels are...

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Source

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Identifiers

PMID: 24465968
DOI: 10.1371/journal.pone.0086218
PMCID: PMC3895043

Genes

CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control.PMID 24465968Read ↗

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