Article

Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation

2023-01-12

Abstract excerpt

<h4>SUMMARY</h4> Microtubules play crucial roles in cellular architecture, intracellular transport, and mitosis. The availability of free tubulin subunits impacts polymerization dynamics and microtubule function. When cells sense excess free tubulin, they trigger degradation of the encoding mRNAs, which requires recognition of the nascent polypeptide by the tubulin-specific ribosome-binding factor TTC5. How TTC5...

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Literature Corpus work: 5049ab72-6e6e-5b28-ba00-12934f67d4c7
DOI: 10.1101/2023.01.12.523749

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