Article

Polyomavirus T-Antigen Induces <i>APOBEC3B</i> Expression using a LXCXE-Dependent and TP53-Independent Mechanism

2018-05-02

Abstract excerpt

<h4>ABSTRACT</h4> APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types. Polyomaviruses and papillomaviruses use dominant oncoproteins to induce APOBEC3B overexpression, perhaps to their own benefit, but little is known...

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Literature Corpus work: 70ce88c8-32fc-508f-9baa-e061d84940f8
DOI: 10.1101/312595

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