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Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses

5 May 2016

Abstract excerpt

UNLABELLED: The APOBEC3 family of DNA cytosine deaminases has important roles in innate immunity and cancer. It is unclear how DNA tumor viruses regulate these enzymes and how these interactions, in turn, impact the integrity of both the viral and cellular genomes. Polyomavirus (PyVs) are small DNA pathogens that contain oncogenic potentials. In this study, we examined the effects of PyV infection on APOBEC3...

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PMID: 27147740
DOI: 10.1128/jvi.00771-16

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