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Research on the influence of APOBEC family on the occurrence, diagnosis, and treatment of various tumors.

Journal of cancer research and clinical oncology - 1 Jan 2023

Yang Jing, Hou Jiali, Li Mengxia

Abstract excerpt

BACKGROUND: Apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) is a family of highly efficient cytidine deaminase enzymes. APOBECs have been proven to deaminate cytidine on single-stranded DNA or RNA. Inducing the deamination of cytosine on the target gene into uracil, which exerts a variety of physiological functions, plays an important role in innate immunity, adaptive immunity, and antiviral. As the...

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PMID: 36222899
DOI: 10.1007/s00432-022-04395-2

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