Article
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.
Nucleic acids research - 2 Nov 2017
Periyasamy Manikandan, Singh Anup K, Gemma Carolina, Kranjec Christian, Farzan Raed, Leach Damien A, Navaratnam Naveenan, Pálinkás Hajnalka L, Vértessy Beata G, Fenton Tim R, Doorbar John, Fuller-Pace Frances, Meek David W, Coombes R Charles, Buluwela Laki, Ali Simak
Abstract excerpt
Cancer genome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) genes as an important source of mutations in diverse cancers, with APOBEC3B (A3B) expression especially correlated with such cancer mutations. To better understand the processes directing A3B over-expression in cancer, and possible therapeutic avenues for targeting...
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