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Article

Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B.

mBio - 23 Dec 2014

Vieira Valdimara C, Leonard Brandon, White Elizabeth A, Starrett Gabriel J, Temiz Nuri A, Lorenz Laurel D, Lee Denis, Soares Marcelo A, Lambert Paul F, Howley Peter M, Harris Reuben S

Abstract excerpt

UNLABELLED: Several recent studies have converged upon the innate immune DNA cytosine deaminase APOBEC3B (A3B) as a significant source of genomic uracil lesions and mutagenesis in multiple human cancers, including those of the breast, head/neck, cervix, bladder, lung, ovary, and other tissues. A3B is upregulated in these tumor types relative to normal tissues, but the mechanism is unclear. Because A3B also has...

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Identifiers

PMID: 25538195
DOI: 10.1128/mBio.02234-14
PMCID: PMC4278539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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