Article

Prioritization of The Zinc finger domain within <i>BCL11A by the</i> Amelioration capability of hemoglobinopathies using CRISPR-Cas9 technology

2023-11-28

Abstract excerpt

BCL11A/EVI9, a zinc-finger protein primarily expressed in brain and hematopoietic cells, plays a central role in lymphocyte development, gamma-globin suppression, spinal neuron development, sensory innervation, neuronal polarity, migration, and is associated with microcephaly and dysregulated brain-related genes, offering therapeutic potential for sickle cell disease. The function of the transcriptional regulator...

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Literature Corpus work: 70c4f3a3-75f6-541e-84e7-7dd28b5e6d3f
DOI: 10.1101/2023.11.28.568974

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