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BCL11A: a potential diagnostic biomarker and therapeutic target in human diseases

21 Oct 2019

Abstract excerpt

Transcription factor B-cell lymphoma/leukemia 11A (BCL11A) gene encodes a zinc-finger protein that is predominantly expressed in brain and hematopoietic tissue. BCL11A functions mainly as a transcriptional repressor that is crucial in brain, hematopoietic system development, as well as fetal-to-adult hemoglobin switching. The expression of this gene is regulated by microRNAs, transcription factors and genetic...

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PMID: 31654056
DOI: 10.1042/bsr20190604

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