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C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies

2 Nov 2023

Abstract excerpt

In humans, specific aberrations in β-globin results in sickle cell disease and β-thalassemia, symptoms of which can be ameliorated by increased expression of fetal globin (HbF). Two recent CRISPR-Cas9 screens, centered on ∼1500 annotated sequence-specific DNA binding proteins and performed in a human erythroid cell line that expresses adult hemoglobin, uncovered four groups of candidate regulators of HbF gene...

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PMID: 37924864
DOI: 10.1016/j.jmb.2023.168343

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