Article

Structural Insights into the DNA-Binding Mechanism of BCL11A: The Integral Role of ZnF6

2024-01-20

Abstract excerpt

The transcription factor BCL11A is a critical regulator of the switch from fetal hemoglobin (HbF: α 2 γ 2 ) to adult hemoglobin (HbA: α 2 β 2 ) during development. BCL11A binds at a cognate recognition site (TGACCA) in the γ-globin gene promoter and represses its expression. DNA-binding is mediated by a triple zinc finger domain, designated ZnF456. Here, we report comprehensive investigation of ZnF456, leverag...

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Literature Corpus work: ec7ac494-3a4f-548a-b89c-aaea559090a5
DOI: 10.1101/2024.01.17.576058

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