Article

Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cells

2026-02-09

Abstract excerpt

<h4>ABSTRACT</h4> BCL11A is a transcription factor crucial for neurodevelopment and hematopoiesis. It regulates the developmental switch from fetal hemoglobin (HbF) to adult hemoglobin and is a major therapeutic target for sickle cell disease and β-thalassemia. BCL11A exists in multiple isoforms, including the L isoform (containing a single two-finger ZF2-3 DNA-binding domain) and the XL isoform (containing two a...

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Literature Corpus work: 85d9d87b-21ca-5cdf-8776-35c1e9542ea1
DOI: 10.64898/2026.02.06.704516

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