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Article

Regulation of the fetal hemoglobin silencing factor BCL11A

1 Mar 2016

Abstract excerpt

The clinical severity of sickle cell disease and β-thalassemia, the major disorders of β-globin, can be ameliorated by increased production of fetal hemoglobin (HbF). Here, we provide a brief overview of the fetal-to-adult hemoglobin switch that occurs in humans shortly after birth and review our current understanding of one of the most potent known regulators of this switching process, the multiple zinc...

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PMID: 26963603
DOI: 10.1111/nyas.13024

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