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Article

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

17 Oct 2022

Abstract excerpt

Analysis of DNA methylation is a valuable tool to understand disease progression and is increasingly being used to create diagnostic and prognostic clinical biomarkers. While conversion of cytosine to 5-methylcytosine (5mC) commonly results in transcriptional repression, further conversion to 5-hydroxymethylcytosine (5hmC) is associated with transcriptional activation. Here we perform the first study integrating...

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PMID: 36251389
DOI: 10.1158/0008-5472.can-22-1123

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